Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice
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چکیده
منابع مشابه
Carnitine Palmitoyltransferase-1b (CPT1b) Deficiency Aggravates Pressure- Overload-Induced Cardiac Hypertrophy due to Lipotoxicity
Running title: He et al.; CPT1b deficiency aggravates pressure-overload-induced cardiac hypertrophy Abstract: Background-Carnitine palmitoyltransferase 1(CPT1) is a rate-limiting step of mitochondrial E
متن کاملCarnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity.
BACKGROUND Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of mitochondrial β-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. The muscle isoform, CPT1b, is the predominant isoform expressed in the heart. It has been suggested that inhibiting CPT1 activity by specific CPT1 inhibitors exerts protective effects against cardiac hypertrophy and heart failur...
متن کاملHeart Failure Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity
Received November 9, 2011; accepted August 17, 2012. From the Departments of Nutrition Sciences (L.H., T.K., Q.L., J.L., P.W., Y.Z., Q.Y., Y.D.) and Pharmacology (J.P.), University of Alabama at Birmingham, and Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL (P.A.W.). The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/...
متن کاملCarnitine Palmitoyltransferase 1b Deficiency Protects Mice from Diet-Induced Insulin Resistance
BACKGROUND Carnitine Palmitoyl Transferase 1 (CPT1) is the rate-limiting enzyme governing long-chain fatty acid entry into mitochondria. CPT1 inhibitors have been developed and exhibited beneficial effects against type II diabetes in short-term preclinical animal studies. However, the long-term effects of treatment remain unclear and potential non-specific effects of these CPT1 inhibitors hampe...
متن کاملCarnitine Palmitoyltransferase 1b Deficient Mice Develop Severe Insulin Resistance After Prolonged High Fat Diet Feeding
BACKGROUND Carnitine palmitoyltransferase 1 (CPT1) is the rate-limiting enzyme governing the entry of long-chain acyl-CoAs into mitochondria. Treatments with CPT1 inhibitors protect against insulin resistance in short-term preclinical animal studies. We recently reported that mice with muscle isoform CPT1b deficiency demonstrated improved insulin sensitivity when fed a High Fat-Diet (HFD) for u...
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ژورنال
عنوان ژورنال: Obesity
سال: 2016
ISSN: 1930-7381
DOI: 10.1002/oby.21665